Figure 8.
AngII and aldosterone coadministration in adrenalectomized mice induces nuclear translocation of MR in β-intercalated cells. Immunofluorescence analyses of MR (green), pendrin (red), nuclei (DAPI; blue), and a merged image in kidneys from adrenalectomized C57BL/6J mice treated with either vehicle (ADx-Veh), AngII (ADx-AngII), or AngII and aldosterone (1.0 μg/d) coadministration (ADx-AngII-Aldo). Arrowheads indicate β-intercalated cells. Scale bars represent 25 μm. DAPI, 4′,6-diamidino-2-phenylindole.