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. 2018 Jan 2;18:4. doi: 10.1186/s12885-017-3916-y

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Comparison of the heterogeneity of PD-L1 expression between PTs and LNMs. The box plot shows the correlation between PD-L1 expression in tumor cells and infiltrating lymphocytes. The Wilcoxon signed-rank test for paired samples was performed to assess statistical significance. a Association between lymphocyte PD-L1 expression in matched PT and LNM specimens. Significantly higher expression was detected in the LNMs. b Association between tumor cell PD-L1 expression in matched PT and LNM specimens. Significantly higher expression was detected in the LNMs. c Correlation between PD-L1 expression in tumor cells and lymphocytes in PTs. No significant differences were observed. d Correlation between PD-L1 expression in tumor cells and lymphocytes in LNMs. No significant differences were observed