Table 2.
Selected single-nucleotide polymorphisms in relation to vitamin D level and breast cancer
| SNP (GWAS SNP) | Risk of low vitamin D | Risk of breast cancer | ||||
|---|---|---|---|---|---|---|
| Allele | Frequency of low/high vitamin Da (n = 1343) | Crude OR of low vitamin D (95% CI) | Adjusted ORb of low vitamin D (95% CI) | Cases/control subjects (n = 4058) | Crude OR (95% CI) | Adjusted ORb (95% CI) |
| rs12239582 (rs12144344) | ||||||
| CC | 224/188 | 1.00 | 1.00 | 290/986 | 1.00 | 1.00 |
| CA | 344/336 | 0.86 (0.67–1.10) | 0.87 (0.67–1.12) | 412/1604 | 0.87 (0.74–1.04) | 0.82 (0.68–0.99) |
| AA | 116/135 | 0.72 (0.53–0.99) | 0.72 (0.52–1.00) | 163/600 | 0.92 (0.74–1.15) | 0.93 (0.73–1.17) |
| Missing | – | – | – | 0/3 | – | – |
| rs705117 | ||||||
| CC | 504/486 | 1.00 | 1.00 | 657/2376 | 1.00 | 1.00 |
| CT | 164/168 | 0.94 (0.73–1.21) | 0.94 (0.73–1.22) | 194/762 | 0.92 (0.77–1.10) | 0.86 (0.71–1.05) |
| TT | 16/5 | 3.06 (1.11–8.44) | 3.38 (1.20–9.49) | 14/55 | 0.92 (0.51–1.67) | 0.94 (0.49–1.81) |
| rs7041 | ||||||
| AA | 213/270 | 1.00 | 1.00 | 332/1149 | 1.00 | 1.00 |
| AC | 341/308 | 1.40 (1.11–1.78) | 1.39 (1.09–1.77) | 397/1521 | 0.90 (0.77–1.07) | 0.88 (0.74–1.05) |
| CC | 130/81 | 2.03 (1.46–2.83) | 2.12 (1.51–2.99) | 136/522 | 0.90 (0.72–1.13) | 0.89 (0.70–1.13) |
| Missing | – | – | – | 0/1 | – | – |
| rs2282679 (rs17467825) | ||||||
| GG | 342/397 | 1.00 | 1.00 | 480/1734 | 1.00 | 1.00 |
| GT | 278/230 | 1.40 (1.12–1.76) | 1.42 (1.13–1.80) | 326/1222 | 0.96 (0.82–1.13) | 0.98 (0.83–1.16) |
| TT | 62/29 | 2.45 (1.56–3.95) | 2.51 (1.56–4.05) | 57/229 | 0.90 (0.66–1.22) | 0.91 (0.66–1.27) |
| Missing | 2/3 | – | – | 2/8 | – | – |
| rs10485165 | ||||||
| TT | 515/501 | 1.00 | 1.00 | 650/2385 | 1.00 | 1.00 |
| TC | 153/144 | 1.04 (0.80–1.35) | 1.03 (0.79–1.34) | 194/735 | 0.97 (0.81–1.16) | 0.99 (0.82–1.20) |
| CC | 16/14 | 1.10 (0.53–2.29) | 1.04 (0.49–2.21) | 21/73 | 1.06 (0.65–1.73) | 1.00 (0.60–1.74) |
| rs198300 (rs156299) | ||||||
| GG | 218/229 | 1.00 | 1.00 | 295/1134 | 1.00 | 1.00 |
| GA | 344/319 | 1.13 (0.89–1.44) | 1.08 (0.84–1.38) | 430/1513 | 1.09 (0.92–1.29) | 1.10 (0.91–1.30) |
| AA | 122/111 | 1.16 (0.84–1.59) | 1.09 (0.79–1.52) | 140/545 | 0.99 (0.79–1.24) | 0.96 (0.75–1.22) |
| Missing | – | – | – | 0/1 | – | – |
| rs4751058 | ||||||
| AA | 496/460 | 1.00 | 1.00 | 614/2286 | 1.00 | 1.00 |
| AG | 174/183 | 0.88 (0.69–1.13) | 0.88 (0.68–1.13) | 234/828 | 1.05 (0.89–1.25) | 1.05 (0.88–1.27) |
| GG | 14/16 | 0.81 (0.39–1.68) | 0.77 (0.36–1.63) | 17/79 | 0.80 (0.47–1.36) | 0.66 (0.38–1.17) |
| rs12295888 (rs12287212) | ||||||
| CC | 270/296 | 1.00 | 1.00 | 367/1384 | 1.00 | 1.00 |
| CT | 321/302 | 1.16 (0.93–1.46) | 1.22 (0.96–1.54) | 402/1435 | 1.06 (0.90–1.24) | 1.05 (0.88–1.24) |
| TT | 93/61 | 1.67 (1.16–2.40) | 1.80 (1.24–2.63) | 96/373 | 0.97 (0.75–1.25) | 0.93 (0.71–1.23) |
| Missing | – | – | – | 0/1 | – | – |
| rs1007392 | ||||||
| GG | 231/267 | 1.00 | 1.00 | 325/1184 | 1.00 | 1.00 |
| GA | 337/310 | 1.26 (0.99–1.59) | 1.31 (1.03–1.67) | 417/1543 | 0.99 (0.84–1.16) | 0.99 (0.83–1.18) |
| AA | 115/82 | 1.62 (1.16–2.26) | 1.78 (1.26–2.52) | 123/462 | 0.97 (0.77–1.23) | 0.91 (0.71–1.17) |
| Missing | 1/0 | – | – | 0/4 | – | – |
| rs2060793 (rs10741657) | ||||||
| AA | 246/194 | 1.00 | 1.00 | 283/1040 | 1.00 | 1.00 |
| AG | 328/323 | 0.80 (0.63–1.02) | 0.78 (0.61–1.00) | 418/1544 | 1.00 (0.84–1.18) | 1.10 (0.92–1.33) |
| GG | 110/142 | 0.61 (0.45–0.84) | 0.58 (0.42–0.81) | 164/606 | 1.00 (0.80–1.24) | 1.04 (0.82–1.32) |
| Missing | – | – | – | 0/3 | – | – |
| rs7944926 (rs12785878) | ||||||
| AA | 297/343 | 1.00 | 1.00 | 423/1436 | 1.00 | 1.00 |
| AG | 299/272 | 1.27 (1.01–1.59) | 1.30 (1.03–1.64) | 366/1400 | 0.89 (0.76–1.04) | 0.91 (0.77–1.08) |
| GG | 88/44 | 2.31 (1.56–3.43) | 2.39 (1.59–3.59) | 76/356 | 0.73 (0.55–0.95) | 0.77 (0.57–1.02) |
| Missing | – | – | – | 0/1 | – | – |
| rs3829251 | ||||||
| AA | 402/435 | 1.00 | 1.00 | 545/1954 | 1.00 | 1.00 |
| AG | 242/210 | 1.25 (0.99–1.57) | 1.30 (1.02–1.64) | 287/1079 | 0.95 (0.81–1.12) | 0.99 (0.83–1.18) |
| GG | 40/14 | 3.09 (1.65–5.77) | 3.26 (1.72–6.17) | 33/160 | 0.74(0.50–1.09) | 0.77 (0.51–1.16) |
| rs2302190 | ||||||
| CC | 451/466 | 1.00 | 1.00 | 566/2122 | 1.00 | 1.00 |
| CT | 211/176 | 1.24 (0.98–1.57) | 1.24 (0.97–1.58) | 268/955 | 1.05(0.89–1.24) | 1.09 (0.91–1.30) |
| TT | 20/13 | 1.59 (0.78–3.23) | 1.45 (0.69–3.02) | 28/109 | 0.96 (0.63–1.47) | 0.99 (0.62–1.58) |
| Missing | 2/4 | – | – | 3/7 | – | – |
GWAS Genome-wide association study, SNP Single-nucleotide polymorphism
aLow vs high vitamin D grouped by calendar month
bAdjusted for age at baseline, year of inclusion, level of education, type of occupation, age at menarche, age at first childbirth, exposure to oral contraceptives, exposure to hormone replacement therapy, height, body mass index, alcohol consumption and smoking