Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 2;217(1):15–17. doi: 10.1083/jcb.201711075

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Steffen and Koehler

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 1. — Schematic showing interactions between the ER and mitochondria in mitochondrial division. ER tubules are intimately associated with the mitochondria at contact sites. Calcium release from the ER induces INF2-mediated actin polymerization, leading to increased contact between the ER and mitochondria. Subsequently, mitochondrial calcium uptake by VDAC pores spikes, and calcium is transported into the matrix via the MCU. Finally, mitochondrial IM constriction is induced, followed by OM constriction. This complex model serves as a starting point for directed studies to dissect key events and components. IMS, intermembrane space.