Table 5.
Disease-based enrichment analyses of the five datasets performed with MetaboAnalyst (SMPDB disease database), MBRole (HMDB disease database) and IPA® (in-house disease database) and MetaCore (based on MeSH and OMIM annotations). When the exact disease/condition of study was not obtained, a similar disease was selected
| Dataset | Disease input | Disease output | Rank | Input number metabolites | Hits output | P-value | Adjusted p-value |
|---|---|---|---|---|---|---|---|
| MetaboAnalyst | |||||||
| ST000091 | Type 1 diabetes mellitus | Diabetes mellitus MODY | 20 | 8 | 2 | 3.40E-02 | 5.84E-01 |
| ST000383 | Type 2 diabetes mellitus | Diabetes mellitus MODY | 4 | 27 | 4 | 8.60E-03 | 6.69E-01 |
| Obesity | Obesity | 31 | 27 | 1 | 9.07E-02 | 8.83E-01 | |
| MTBLS364 | Smokers | – | – | 81 | – | – | – |
| MTBLS424 | Breast cancer | Mammary tumour | 30 | 22 | 2 | 4.08E-03 | 4.68E-02 |
| ST000284 | Colorectal cancer | Cervical/colon/ovarian cancer | 46 | 42 | 1 | 8.47E-02 | 5.30E-01 |
| MBRole | |||||||
| ST000091 | Type 1 diabetes mellitus | – | – | 8 | – | – | – |
| ST000383 | Type 2 diabetes mellitus | Type 2 diabetes mellitus | 8 | 27 | 3 | 1.16E-02 | 5.48E-02 |
| Obesity | Obesity | 28 | 27 | 1 | 1.08E-01 | 1.48E-01 | |
| MTBLS364 | Smokers | Lung Cancer | 16 | 81 | 31 | 3.02E-02 | 9.25E-02 |
| MTBLS424 | Breast cancer | Lung Cancer | 7 | 22 | 6 | 1.27E-04 | 1.09E-03 |
| ST000284 | Colorectal cancer | Colorectal cancer | 44 | 42 | 1 | 5.19E-02 | 1.14E-01 |
| IPA® | |||||||
| ST000091 | Type 1 diabetes mellitus | – | – | 8 | – | – | – |
| ST000383 | Type 2 diabetes mellitus | Insulin resistance | 21 | 27 | 3 | 6.10E-05 | NA |
| Obesity | Adipogenesis of fat | 264 | 27 | 1 | 1.54E-02 | NA | |
| MTBLS364 | Smokers | Cough | 490 | 81 | 11 | 4.33E-02 | NA |
| MTBLS424 | Breast cancer | Gastric cancer | 2 | 22 | 9 | 5.03E-11 | NA |
| ST000284 | Colorectal cancer | Colorectal cancer | 3 | 42 | 11 | 2.31E-08 | NA |
| MetaCore™ | |||||||
| ST000091 | Type 1 diabetes mellitus | Type 1 diabetes mellitus | NA | 8 | 0 | NA | NA |
| ST000383 | Type 2 diabetes mellitus | Type 2 diabetes mellitus | NA | 27 | 7 | NA | NA |
| Obesity | Obesity | NA | 27 | 1 | NA | NA | |
| MTBLS364 | Smokers | Respiratory disorders | NA | 81 | 1 | NA | NA |
| MTBLS424 | Breast cancer | Breast neoplasms | NA | 22 | 0 | NA | NA |
| ST000284 | Colorectal cancer | Colorectal neoplasms | NA | 42 | 13 | NA | NA |
Abbreviations: NA not available