Figure 3.
Repetitive depolarizations cause CDF for Cav2.1 but not Cav2.2. (A–C) ICa or IBa were evoked by 2-ms steps from −80 mV to 0 mV for ICa or −10 mV for IBa at 100 Hz in cells transfected with Cav2.1 (A) or Cav2.2 containing exon 37b (B) or exon 37a (C). The amplitude of each current was normalized to the first current of the train and plotted against pulse number. For clarity, every fifth point is plotted. Numbers of cells for ICa and IBa are indicated in Table 2. Data represent mean ± SEM.