Table 3. FCDF calculated from F96–100 for ICa and IBa from 100-Hz protocol.
Construct | F96-100 for ICa | F96-100 for IBa | P-value, ICa vs. IBaa | FCDF | P-value vs. Cav2.1b | P-value vs. Cav2.2ab |
---|---|---|---|---|---|---|
Cav2.2-CT2.1 | 1.09 ± 0.03 (15) | 0.89 ± 0.03 (15) | <0.001 | 0.20 ± 0.03 (15) | 1.000 | |
Cav2.2-pCT2.1 | 1.07 ± 0.02 (13) | 0.93 ± 0.02 (11) | <0.001 | 0.14 ± 0.02 (13) | 0.370 | |
Cav2.2-dCT2.1 | 0.90 ± 0.03 (8) | 0.92 ± 0.02 (10) | 0.914 | 0.02 ± 0.03 (8) | <0.001 | |
Cav2.2-EF2.1 | 0.85 ± 0.03 (10) | 0.88 ± 0.03 (10) | 0.520 | −0.03 ± 0.03 (10) | <0.001 | |
Cav2.2-pre-IQ-IQ2.1 | 0.90 ± 0.03 (10) | 0.92 ± 0.02 (12) | 0.583 | −0.02 ± 0.03 (10) | <0.001 | |
Cav2.2-CBD2.1 | 0.99 ± 0.03 (10) | 0.93 ± 0.02 (11) | 0.149 | 0.06 ± 0.03 (10) | 0.006 | |
Cav2.2-pre-IQ-IQ-CBD2.1 | 0.95 ± 0.02 (11) | 0.95 ± 0.04 (6) | 0.689 | 0.00 ± 0.02 (11) | <0.001 | |
Cav2.2-EF&CBD2.1 | 0.89 ± 0.03 (12) | 0.86 ± 0.02 (10) | 0.508 | 0.03 ± 0.03 (12) | 0.001 | |
Cav2.2-EF-pre-IQ-IQ2.1 | 1.07 ± 0.03 (18) | 0.94 ± 0.03 (13) | 0.004 | 0.13 ± 0.03 (18) | 0.851 | |
Cav2.1-CT2.2 | 1.08 ± 0.04 (10) | 1.08 ± 0.02 (5) | 0.966 | 0.00 ± 0.04 (10) | 1.000 | |
Cav2.1-pCT2.2 | 1.05 ± 0.02 (5) | 1.01 ± 0.02 (7) | 0.073 | 0.04 ± 0.02 (5) | 1.000 | |
Cav2.1-dCT2.2 | 1.24 ± 0.03 (4) | 1.02 ± 0.02 (3) | 0.024 | 0.22 ± 0.03 (4) | 0.054 | |
Cav2.1-EF2.2 | 1.08 ± 0.03 (4) | 1.02 ± 0.02 (6) | 0.257 | 0.06 ± 0.03 (4) | 1.000 | |
Cav2.1-pre-IQ-IQ2.2 | 1.03 ± 0.01 (8) | 1.03 ± 0.02 (6) | 0.831 | 0.00 ± 0.02 (8) | 1.000 | |
Cav2.1-CBD2.2 | 1.27 ± 0.02 (8) | 1.04 ± 0.04 (10) | <0.001 | 0.23 ± 0.02 (8) | 0.005 | |
Cav2.1-EF-pre-IQ-IQ2.2 | 1.05 ± 0.01 (11) | 1.06 ± 0.02 (11) | 0.645 | −0.01 ± 0.00 (11) | 1.000 |
FCDF and F96-100 (mean ± SEM) were determined as indicated in the text. Number of cells in parentheses.
Determined by Student’s t test.
Determined by Kruskal–Wallis test and post-hoc Dunn's test.