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. 2017 Dec 26;23:6121–6131. doi: 10.12659/MSM.907401

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© Med Sci Monit, 2017

This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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Effects of pioglitazone treatment on RAGE and PPAR-γ expressions in atherosclerotic plaques of ApoE^−/− diabetic mice by immunohistochemical analysis. Representative immunohistochemical staining images (A) and quantitative analysis (B) showing RAGE protein expression in atherosclerotic plaques. Representative immunohistochemical staining images (C) and quantitative analysis (D) showing PPAR-γ protein expression in atherosclerotic plaques. C – control group; D – diabetic group; D + P − diabetic + pioglitazone group; D + P + G − diabetic + pioglitazone + GW9662 group. * p<0.05. N=8 per group.