Figure 1.

Components of the actin cytoskeleton in migrating cells. (A) Illustration of the components of the actin cytoskeleton in representative fibroblast-like cells. The direction of cell migration is indicated by wide gray arrows. (B) Fluorescence micrograph of a rat embryo fibroblast showing actin filaments (cyan) and myosin II (red). (C) Electron micrograph of the cytoskeleton of a Xenopus laevis fibroblast prepared by platinum shadowing after detergent extraction and critical point drying. Individual components of the actin cytoskeleton are marked in all panels. Scale bars, 10 µm. (C, Adapted from Svitkina and Borisy 1999.)