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. 2017 Nov 1;31(21):2175–2185. doi: 10.1101/gad.303677.117

Figure 6.

Figure 6.

Model. Following cleavage and polyadenylation of the transcript, the CID of PCF11 is transiently phosphorylated by WNK1. This weakens the interaction between the PCF11 CID and the Pol II CTD, leading to the dissociation and release of mRNP from transcription loci. As a result, nuclear export of mRNA is promoted.