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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Nat Med. 2017 Jul 31;23(9):1095–1101. doi: 10.1038/nm.4377

Figure 3. Human genetic variation significantly impacts CRISPR endonuclease therapeutic safety.

Figure 3

a, Schematic illustrating off-target candidates arising due to multiple different haplotypes. MM, mismatch. b, Number of off-target candidates present in the 1000 Genomes dataset for each CRISPR endonuclease for 12 therapeutically relevant genes at different allele frequencies. c, Distribution of the number of off-target candidates per platinum target for each CRISPR endonuclease. d, Distribution of the number of off-target candidates per enzyme for the 4 CRISPR endonucleases studied here.