Table 3.
Associations between miRNA-binding-site polymorphisms in DNA DSB repair genes and recurrence risk of patients with HPV16-positive SCCOP (N = 324)
| Genotype | No. of recurrences/no. of patients | 5-year recurrence rate | Log-rank P value | Adjusted HR* (95% CI) |
|---|---|---|---|---|
| ATM rs227091 | 0.570 | |||
| TT† | 29/183 | 0.15 | 1.0 | |
| TC/CC | 16/141 | 0.13 | 0.7 (0.3-1.7) | |
| BRCA1 rs12516 | 0.004 | |||
| CC† | 33/161 | 0.26 | 1.0 | |
| CT/TT | 12/163 | 0.10 | 0.2 (0.1-0.6) | |
| BRCA1 rs8176318 | 0.372 | |||
| GG† | 27/223 | 0.15 | 1.0 | |
| GT/TT | 18/101 | 0.18 | 1.3 (0.6-3.0) | |
| PARP1 rs8679 | 0.430 | |||
| TT | 29/264 | 0.17 | 1.0 | |
| TC/CC | 16/60 | 0.22 | 1.4 (0.6-3.7) | |
| LIG3 rs4796030 | 0.613 | |||
| CC† | 12/76 | 0.16 | 1.0 | |
| CA/AA | 33/248 | 0.15 | 0.8 (0.3-2.0) | |
| NBS1 rs2735383 | 0.738 | |||
| GG† | 22/168 | 0.17 | 1.0 | |
| GC/CC | 23/156 | 0.15 | 1.2 (0.6-2.7) | |
| NBS1 rs1063054 | 0.547 | |||
| AA† | 27/233 | 0.16 | 1.0 | |
| AC/CC | 18/91 | 0.18 | 1.4 (0.6-3.5) | |
| NBS1 rs1063053 | 0.529 | |||
| CC† | 33/254 | 0.15 | 1.0 | |
| CT/TT | 12/70 | 0.16 | 1.4 (0.6-3.5) | |
| RAD51 RS7180135 | 0.003 | |||
| AA† | 40/202 | 0.26 | 1.0 | |
| AG/GG | 5/122 | 0.10 | 0.2 (0.0-0.7) |
HR, hazard ratio.
*
Adjusted for age, sex, ethnicity, smoking status, alcohol use status, stage, comorbidity, and treatment.
†
Reference group.