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. 2017 Dec;58(14):6513–6528. doi: 10.1167/iovs.17-23544

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Copyright 2017 The Authors

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Effect of adherence to the alternate Mediterranean diet (aMeDi) on progression to advanced AMD according to CFH Y402H genotypes. HRs and 95% CIs were estimated by using Cox proportional hazards models with individual eye as the unit of analysis, adjusted for age, sex, AMD status at baseline for both eyes, AREDS treatment, total energy intake, educational level, smoking, BMI, supplement use, and the other nine genetic variants (CFH rs1410996, CFH rs121913059 [R1210C], ARMS2/HTRA1 rs10490924, C2 rs9332739 [E318D], CFB rs641153 [R32Q], C3 rs2230199 [R102G], C3 rs147859257 [K155Q], COL8A1 rs13095226, and RAD51B rs8017304). P trend was calculated by using median values within each category. Low aMeDi score (0–3) was the referent. Reprinted with permission from Merle BM, Silver RE, Rosner B, Seddon JM. Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study. Am J Clin Nutr. 2015;102:1196–1206. Copyright 2015 American Society for Nutrition.