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. Author manuscript; available in PMC: 2019 Jan 15.
Published in final edited form as: Gen Comp Endocrinol. 2017 Jun 17;256:123–129. doi: 10.1016/j.ygcen.2017.05.023

Table 1.

Missing genes in birds that affect endocrine related organ systems/functions when knocked out singly or in combinations with other genes in mice (Modified from Lovell et al., 2014; classifications based on MGI; www.informatix.jax.org)

Organ/System MGI Phenotype (single knockout)i MGI Phenotype (multiple knockouts)ii Pubmed/Entrez Geneiii
insulin, pancreas, lipids ABCD1, APOM, BCAT2, CPT1C, ESRRA, FGF21, GSK3A, NR1H2, RETN, RIPK3, RLN3, SERPINI2, SERTAD1 SLC6A8 BGN, LRP10, NFATC4, PPP1R3E
weight and eating APEX2, APLP1, ARAF, AVPR2, BCAT2, BGN, CPT1C, ERF, ESRRA, FGF21, GSK3A, MARCH9, PRKACA, PRSS8, RLN3, SERPINI2, SLC6A8, SLC7A7, TIMP1 CDKN2D, EPN1, MAMSTR, RAB3D NTF4
gametes, gonads, reproduction CCDC159, CCNB1IP1, CDKN2D, ELK1, GAPDHS, PRKACA, SLC7A7, TBX6, TIMP1 BGN, EGLN2, EPN1, NR1H2, PARP2, POU5F1 ASF1B, DNAAF3, GAPDHS, IZUMO2, RLN3, TSKS, TSSK4
i

single knockout sufficient to cause endocrine phenotype;

ii

endocrine phenotype requires knockout of this gene combined with other genes;

iii

links to endocrine function based on published literature on gene function and Entrez Gene summaries