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. Author manuscript; available in PMC: 2018 Dec 21.
Published in final edited form as: Cell Chem Biol. 2017 Oct 19;24(12):1490–1500.e11. doi: 10.1016/j.chembiol.2017.09.003

Figure 3. Analysis of USP7 mutant proteins.

Figure 3

A) Detailed ligand interaction diagram of XL188 with USP7. Residues for which >80% of other USPs contain an amino acid belonging to the same class are boxed red.

B) Summary of activity against Ub-AMC and inhibition by 1 for USP7 mutant catalytic domain proteins.

C) Dose-response inhibition of full length USP7WT and USP7Q351 (amino acids 1–1102) by 1.

D) Dose-response inhibition of full length USP7WT and USP7Q351 (amino acids 1–1102) by XL188.

See also Figure S4.