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. 2017 Jun 14;66(12):2110–2120. doi: 10.1136/gutjnl-2017-313856

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Small intestinal postoperative ileus is induced by Ly6C⁺ monocytes or Ly6C^– macrophages. (A–C) Abundance of Ly6C^–F4/80⁺ macrophages (MPs) (A), Ly6C⁺F4/80⁺ monocytes (B) and Ly6C⁺CD115⁺ monocytes (C) after sham (A) or small intestinal manipulation (SIM) in the small intestinal muscularis (B) or in the blood (C) of Cx₃cr1-Cre⁺ iDtr^flox/+ (BM-iDTR) or C57Bl/6 (BM-WT) bone marrow chimeras treated with diphtheria toxin (+DT) or left untreated (–DT) (representative data of n=7). (D,E) Measurement of small intestinal motility 24 hours after SIM or sham in Cx₃cr1-Cre⁺ iDtr^flox/+ (BM-iDTR) or C57Bl/6 (BM-WT) mice (SIM n=11, SIM DT and CloLip n=7, sham n=4) (FITC-Dex=Fluorescein isothiocyanate-dextran, S=stomach, 1–10=small intestinal segments, Z=caecum, C1-3=large intestinal segments). GC=geometric centre; CloLip=clodronate liposomes. Results are given as mean +/− SEM. *p<0.05; **p<0.01; ***p<0.001.