Table 2.
Comparisons of control rats and rats given hyaluronidase (HAase) at 1 week and 4 weeks. Values show means and inter-quartile ranges (IQRs)
| 1W | 4W | |||||
|---|---|---|---|---|---|---|
| Control (N=6) | HAase (N=6) | P-value | Control (N=6) | HAase (N=6) | P-value | |
| Weight(g) | 271.5 (257-279.3) | 268.5 (258.8-286) | 0.818 | 268 (254.5-275.5) | 268 (260.8-274.5) | 0.937 |
| Urination frequency (per day) | 11.5 (10.5-13) | 21.5 (19.8-23.5) | 0.002 | 12.5 (11.8-13.3) | 38.5 (34.5-42)* | 0.002 |
| Daily urine volume (ml) | 1.6 (1.5-1.9) | 0.8 (0.7-0.9) | 0.002 | 1.6 (1.5-1.8) | 0.3 (0.2-0.4)* | 0.002 |
| Inflammation score | 0 (0-0.3) | 2(1.8-2) | 0.002 | 0 (0-1) | 3(2.8-3)* | 0.002 |
| Number of inflammatory cells | 3 (2-5) | 181.5 (171-217.8) | 0.002 | 4 (2-7) | - | - |
| TSG-6 mRNA | 0.2 (0.2-0.3) | 0.6 (0.6-0.7) | 0.002 | 0.2 (0.2-0.3) | 0.8 (0.7-0.8)* | 0.002 |
| IL-6 mRNA | 0.4 (0.4-0.5) | 0.7 (0.6-0.7) | 0.002 | 0.5 (0.4-0.5) | 0.9 (0.8-0.9)* | 0.002 |
| IL-6 protein | 0.5 (0.5-0.6) | 1.3 (1.2-1.5) | 0.002 | 0.5 (0.5-0.6) | 2.1 (1.9-2.2)* | 0.002 |
| Uroplakin III(IOD) | 690 (659.8-720.8) | 83.5 (75-89.3) | 0.002 | 688.5 (672.3-722.3) | 22.5 (20.3-28)* | 0.002 |
| TSG-6 (IOD) | 1094.5 (998.8-1157.3) | 12932.5 (12141-13291.8) | 0.002 | 1148 (998.3-1208.5) | 21443 (19973.3-22330.8)* | 0.002 |
*
P<0.05, significantly different from the HAase 1W group. TSG-6: tumor necrosis factor-inducible gene 6