Table 3.
Comparisons of rats in the control 1W, HAase 1W/TSG-6, and HAase 1W/PBS groups
| Control 1W (N=6) | HAase 1W/TSG-6 (N=6) | HAase 1W/PBS (N=6) | P-value | |
|---|---|---|---|---|
| Weight(g) | 271.5 (257-279.3) | 265.5 (254.8-277) | 267 (258.8-276.8) | 0.884 |
| Urination frequency (per day) | 11.5 (10.5-13) | 14.5 (13.8-15.3) | 22 (20.3-26.5)* | 0.001 |
| Daily urine volume (ml) | 1.6 (1.5-1.9) | 1.6 (1.4-1.7) | 0.9 (0.7-0.9)*† | 0.003 |
| Inflammation score | 0 (0-0.3) | 1 (1-1.3)* | 1.5 (1-2)* | 0.004 |
| Number of inflammatory cells | 3 (2-5) | 77.5 (64.3-112.5) | 184 (175.3-205.3)* | <0.001 |
| TSG-6 mRNA | 0.2 (0.2-0.3) | 0.6 (0.6-0.7)* | 0.5 (0.5-0.6) | 0.001 |
| IL-6 mRNA | 0.4 (0.4-0.5) | 0.6 (0.5-0.6) | 0.6 (0.5-0.8)* | 0.005 |
| IL-6 protein | 0.5 (0.5-0.6) | 0.9 (0.8-1.1) | 1.3 (1.2-1.4)* | 0.001 |
| Uroplakin III (IOD) | 690 (659.8-720.8) | 676.5 (651.8-703.8) | 80.5 (74.5-87.3)*† | 0.003 |
| TSG-6 (IOD) | 1094.5 (998.8-1157.3) | 14110.5 (13748.3-14362.3)* | 12781 (12040-13239.8) | 0.001 |
*
P<0.05, significantly different with control 1W
†
P<0.05, significantly different with HAase 1W/TSG-6. TSG-6: tumor necrosis factor-inducible gene 6, HAase: hyaluronidase, PBS: phosphate-buffered saline