Table 2.
Clinical outcomes of patients in the conservative management and initial AVR cohorts
| Normal LVMI N of patients with event/N of patients at risk (cumulative 5-year incidence (%)) |
High LVMI N of patients with event/N of patients at risk (cumulative 5-year incidence (%)) |
Unadjusted | Adjusted | |||||
| HR (95% CI) |
p Value | HR (95% CI) |
p Value | p Value for interaction | ||||
| A composite of aortic valve-related death or hospitalisation due to heart failure | Conservative management cohort | 164/691 (33) | 582/1480 (49) | 1.93 (1.63 to 2.31) |
<0.001 | 1.53 (1.26 to 1.85) |
<0.001 | 0.016 |
| Initial AVR cohort | 26/217 (14) | 123/894 (16) | 1.12 (0.75 to 1.75) |
0.59 | 0.96 (0.60 to 1.55) |
0.88 | ||
| All-cause death | Conservative management cohort | 257/691 (42) | 684/1480 (52) | 1.36 (1.18 to 1.57) |
<0.001 | 1.11 (0.94 to 1.30) |
0.23 | 0.39 |
| Initial AVR cohort | 34/217 (19) | 176/894 (23) | 1.19 (0.84 to 1.75) |
0.33 | 0.92 (0.61 to 1.39) |
0.69 | ||
| Aortic valve-related death | Conservative management cohort | 86/691 (17) | 335/1480 (31) | 1.98 (1.57 to 2.53) |
<0.001 | 1.52 (1.18 to 1.96) |
0.001 | 0.42 |
| Initial AVR cohort | 8/217 (5) | 51/894 (6) | 1.53 (0.77 to 3.48) |
0.24 | 1.42 (0.65 to 3.08) |
0.38 | ||
| Heart failure hospitalisation | Conservative management cohort | 130/691 (28) | 471/1480 (43) | 1.98 (1.64 to 2.42) |
<0.001 | 1.64 (1.33 to 2.02) |
<0.001 | 0.0034 |
| Initial AVR cohort | 18/217 (10) | 76/894 (12) | 0.99 (0.61 to 1.71) |
0.98 | 0.89 (0.50 to 1.57) |
0.68 | ||
Other abbreviations are same as in table 1.
AVR, aortic valve replacement; LVMI, left ventricular mass index.