Table 1.
Characteristics of development and validation cohorts (n = 7262)
| Cohort | ||
|---|---|---|
|
|
||
| Feature | Development N = 4357 |
Validation N =2905 |
| Demographic features | ||
| Age (years, mean) | 64 ± 11 | 64 ± 11 |
| Male (%) | 64% | 65% |
| Black race (%) | 11% | 11% |
| Hispanic ethnicity (%) | 3% | 4% |
| Physical examination | ||
| BMI (kg/m2, mean) | 28 ± 5 | 28 ± 6 |
| Abdominal obesity | 52% | 51% |
| SBP (mmHg, mean) | 136 ± 19 | 137 ± 19 |
| DBP (mmHg, mean) | 81 ± 11 | 81 ± 11 |
| Modified Rankin Scale score (mean) | .9 ± 1.0 | .9 ± 1.0 |
| Laboratory data | ||
| HOMA-IR (mean) | 4.5 ± 4.1 | 4.4 ± 3.3 |
| LDL (mmol/L, mean) | 88 ± 32 | 89 ± 32 |
| HDL (mmol/L, mean) | 49 ± 13 | 50 ± 15 |
| TG (mg/dL, mean) | 128 ± 67 | 129 ± 69 |
| TG/HDL (mean) | 3.0 ± 2.1 | 3.0 ± 2.4 |
| Fasting glucose (mg/dL) (mean) | 97 ± 13 | 97 ± 16 |
| Fasting insulin (µU/mL) (mean) | 18 ± 13 | 18 ± 11 |
| Randomized into IRIS (no.) | 2245 | 1465 |
Abbreviations: BMI, body mass index; DBP, diastolic blood pressure; HDL, high-density lipoprotein; HOMA-IR, homeostasis model assessment of insulin resistance; LDL, low-density lipoprotein; SBP, systolic blood pressure; TG, triglyceride.
Missing data:
Development: race (14); ethnicity (14); BMI (20); abdominal obesity (54); SBP (12); DBP (12); modified Rankin Scale (4); LDL (45); HDL (17); TG (16); TG/HDL ratio (17).
Validation: race (18); ethnicity (20); BMI (13); abdominal obesity (54); SBP (7); DBP (7); modified Rankin Scale (1); LDL (29); HDL (11); TG (10); TG/HDL ratio (11).