Table 5.

Performance of the enhanced instrument

Development cohort (n = 4278)
Score cutoff (greater than or equal to)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	No. of patients with score less than cutoff
0	100	0	64	—	0
1	97	15	67	77	312
2	93	32	70	72	688
3	85	50	75	66	1184
4	77	61	78	60	1579
5	68	73	81	56	2019
6	55	83	85	52	2509
7	44	91	89	48	2921
8	31	95	92	44	3364
9	24	97	93	42	3591
10	14	99	95	40	3888
11	9	99	97	39	4016
13	3	100	97	37	4190
Validation cohort (n = 2837)
Score cutoff (greater than or equal to)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	No. of patients with score less than cutoff
0	100	0	64	—	0
1	98	16	68	81	204
2	93	35	72	75	480
3	86	53	76	68	799
4	78	64	80	62	1066
5	68	74	82	56	1337
6	55	84	86	51	1664
7	44	90	88	47	1941
8	29	95	92	43	2255
9	24	97	94	42	2370
10	14	99	96	39	2569
11	9	100	98	38	2672
12	2	100	100	36	2797
13	2	100	100	36	2798

Abbreviations: NPV, negative predictive value; PPV, positive predictive value.