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. Author manuscript; available in PMC: 2018 Jan 2.
Published in final edited form as: J Stroke Cerebrovasc Dis. 2016 Apr 11;25(7):1705–1712. doi: 10.1016/j.jstrokecerebrovasdis.2016.03.043

Table 5.

Performance of the enhanced instrument

Development cohort (n = 4278)
Score cutoff (greater than or equal to) Sensitivity (%) Specificity (%) PPV (%) NPV (%) No. of patients with score less than cutoff
0 100 0 64 — 0
1 97 15 67 77 312
2 93 32 70 72 688
3 85 50 75 66 1184
4 77 61 78 60 1579
5 68 73 81 56 2019
6 55 83 85 52 2509
7 44 91 89 48 2921
8 31 95 92 44 3364
9 24 97 93 42 3591
10 14 99 95 40 3888
11 9 99 97 39 4016
13 3 100 97 37 4190
Validation cohort (n = 2837)
Score cutoff (greater than or equal to) Sensitivity (%) Specificity (%) PPV (%) NPV (%) No. of patients with score less than cutoff
0 100 0 64 — 0
1 98 16 68 81 204
2 93 35 72 75 480
3 86 53 76 68 799
4 78 64 80 62 1066
5 68 74 82 56 1337
6 55 84 86 51 1664
7 44 90 88 47 1941
8 29 95 92 43 2255
9 24 97 94 42 2370
10 14 99 96 39 2569
11 9 100 98 38 2672
12 2 100 100 36 2797
13 2 100 100 36 2798

Abbreviations: NPV, negative predictive value; PPV, positive predictive value.