Table 1.
Results Summary
| Case # | Somatic Mutations | Matches** | Copy Number Similarity/Rank*** |
|||
|---|---|---|---|---|---|---|
| Left | Right | Shared | P-Value* | |||
| 1 | 9 | 7 | 0 | 1.0 | −1.78 / 43 | |
| 2 | 3 | 3 | 0 | 1.0 | 0.76 / 20 | |
| 3 | 2 | 7 | 0 | 1.0 | 0.57 / 22 | |
| 4 | 8 | 10 | 0 | 1.0 | −1.75 / 42 | |
| 6 | 6 | 5 | 0 | 1.0 | 0.55/ 23 | |
| 8 | 6 | 2 | 1 | 0.004 | ARID1A E250fs | 3.74 / 2 |
| 9 | 2 | 3 | 0 | 1.0 | −1.16/ 35 | |
| 12 | 14 | 3 | 0 | 1.0 | −4.09 / 49 | |
| 13 | 3 | 3 | 0 | 1.0 | −0.22 / 28 | |
| 15 | 8 | 5 | 0 | 1.0 | −1.92 / 44 | |
| 16 | 10 | 8 | 0 | 1.0 | −2.65 / 47 | |
| 17 | 6 | 8 | 0 | 1.0 | −0.14/ 26 | |
| 18 | 8 | 2 | 0 | 1.0 | 2.37 / 5 | |
| 21 | 4 | 3 | 0 | 1.0 | 0.29 / 24 | |
| 23 | 10 | 4 | 0 | 1.0 | −1.47 / 40 | |
| 24 | 4 | 3 | 0 | 1.0 | 1.76/ 8 | |
| 25 | 4 | 6 | 0 | 1.0 | −0.32 / 30 | |
| 26 | 6 | 5 | 0 | 1.0 | 1.57 / 11 | |
| 27 | 4 | 5 | 0 | 1.0 | 1.38 / 13 | |
| 29 | 3 | 1 | 0 | 1.0 | −0.28 / 29 | |
| 30 | 6 | 5 | 0 | 1.0 | −1.18 / 36 | |
| 31 | 6 | 5 | 0 | 1.0 | −1.21 / 37 | |
| 32 | 5 | 4 | 0 | 1.0 | −0.98 / 34 | |
| 33 | 6 | 4 | 0 | 1.0 | 1.80 / 7 | |
| 35 | 5 | 4 | 0 | 1.0 | −0.01 / 25 | |
| 36 | 3 | 4 | 3 | <0.001 | CDH1 S111fs; TBX3 T267fs; EPPK1 R2337H | 4.46 / 1 |
| 38 | 8 | 2 | 0 | 1.0 | −1.60 / 41 | |
| 40 | 10 | 1 | 0 | 1.0 | 2.68 / 4 | |
| 41 | 0 | 9 | -- | 1.0 | 1.12 / 17 | |
| 43 | 4 | 4 | 0 | 1.0 | −0.69 / 33 | |
| 44 | 9 | 21 | 0 | 1.0 | −2.32 / 46 | |
| 45 | 3 | 4 | 0 | 1.0 | 1.24 / 15 | |
| 48 | 2 | 3 | 2 | <0.001 | MLH3 M346R; MAP3K1 R248* | 3.01 / 3 |
| 52 | 5 | 7 | 0 | 1.0 | 2.23 / 6 | |
| 56 | 2 | 5 | 0 | 1.0 | 1.51 / 12 | |
| 58 | 3 | 4 | 0 | 1.0 | −1.25 / 38 | |
| 59 | 2 | 3 | 0 | 1.0 | 0.83 / 19 | |
| 62 | 4 | 4 | 0 | 1.0 | −0.17 / 27 | |
| 63 | 3 | 9 | 1 | 0.08 | PIK3CA H1047R | 0.98 / 18 |
| 64 | 5 | 4 | 0 | 1.0 | 0.63 / 21 | |
| 66 | 33 | 3 | 0 | 1.0 | 1.34 / 14 | |
| 67 | 4 | 1 | 1 | 0.08 | PIK3CA H1047R | 1.75 / 9 |
| 70 | 5 | 2 | 0 | 1.0 | −2.95 / 48 | |
| 71 | 3 | 1 | 0 | 1.0 | 1.21 / 16 | |
| 72 | 1 | 3 | 0 | 1.0 | −2.19 / 45 | |
| 74 | 2 | 1 | 0 | 1.0 | −0.66 / 32 | |
| 75 | 4 | 3 | 1 | 0.08 | PIK3CA H1047R | −1.36 / 39 |
| 76 | 7 | 5 | 0 | 1.0 | 1.70 / 10 | |
| 77 | 3 | 1 | 0 | 1.0 | −0.60 / 31 | |
*
P-value for the test of clonal relatedness of the tumor pair.
**
Matches were validated either by re-sampling the tumor and resequencing if sufficient tumor was available or by targeted sequencing (MiSeq), or by Sanger sequencing.
***
Log likelihood ratio measure of similarity of copy number profiles and ranking