TABLE 4.
Candidate Antral Follicle Regulatory Growth Factor Receptors
| Microarray signal
|
||||||
|---|---|---|---|---|---|---|
| Gene symbol | S | M | L | Genbank | Receptor description |
Ligand |
| (A) Bovine granulosa cell growth factor receptors | ||||||
| Cxcr4 | 96 | 53 | 460 | NM_174301.3 | Chemokine (C-X-C motif) receptor 4 | SDF1 |
| Ccr1 | 35 | 53 | 264 | CK773226 | Chemokine (C-C motif) receptor 1 | CCL5 |
| Cxcr3 | ND | ND | 63 | CK774970 | Chemokine receptor 3 | CCL3L1 |
| Ccr5 | ND | ND | 70 | AW658666 | Chemokine receptor 5 | MIP1 |
| Flk1 | 22 | 24 | 19 | CB166172 | Tyrosine kinase receptor | VEGF |
| Cxcr6 | ND | ND | 158 | CB170970 | Chemokine (C-X-C motif) receptor 6 | CXC16 |
| TgfbR1 | 18 | 24 | 40 | NM174621.2 | Transforming growth factor beta receptor 1 | TGFB1 |
| Loc504429 | 704 | 534 | 797 | AW345638 | Similar to MER receptor tyrosine kinase | GAS6 |
| Loc516598 | 656 | 715 | 837 | BF440555 | Similar to AXL receptor tyrosine kinase | GAS6 |
| Loc788224 | 813 | 507 | 710 | AW313997 | Similar to RSE receptor tyrosine kinase | GAS6 |
| (B) Bovine theca cell growth factor receptors | ||||||
| Ccr1 | 57 | 43 | 59 | CK773226 | Chemokine (C-C motif) receptor 1 | CCL5 |
Bold lines are genes that increase (S < M < L) during antral follicle development. Raw microarray signal for cells from small (S), medium (M), or large (L) follicles.