Table 1.
Demographic, baseline clinical characteristics and exercise outcomes
| Variable | Total | Fried Frailty Phenotype Score
|
||
|---|---|---|---|---|
| Not frail (score 0–1) |
Intermediate (Score 2–3) |
Frail (Score 4) |
||
| No. of participants (% of total) | 68 | 20 (29) | 40 (59) | 8 (12) |
| Weeks between CPET and frailty score | 6 ± 5 | 6 ± 6 | 5 ± 5 | 6 ± 5 |
| Female, n (%) | 35 (51%) | 5 (25%) | 25(63%) | 5 (63%) |
| Age, years | 57 ± 11 | 57 ± 12 | 55 ± 11 | 58 ± 11 |
| Body mass index, kg/m2 | 25.4 ± 5.0 | 26.5 ± 4.1 | 25.3 ± 5.4 | 22.5± 4.3 |
| Race, n (%) | ||||
| Caucasian | 54 (79%) | 18 (90%) | 31 (77%) | 5 (63%) |
| Black | 5 (7%) | 0 | 3 (8%) | 2 (25%) |
| Hispanic | 4 (6%) | 0 | 3 (8%) | 1 (13%) |
| Asian | 5 (7%) | 2 (10%) | 3 (8%) | 0 |
| Diagnosis, n (%) | ||||
| COPD | 22 (32%) | 3 (15%) | 14 (35%) | 5 (63%) |
| CF | 7 (11%) | 3 (15%) | 3 (8%) | 1 (13%) |
| ILD | 39 (57%) | 14 (70%) | 23 (58%) | 2 (25%) |
| LAS | 40.2 ± 13.5 | 39.6 ± 13.6 | 40.7 ± 14.2 | 39.1 ± 10.2 |
| FVC % predicted | 53 ± 16 | 58 ± 18 | 51 ± 15 | 55 ± 17 |
| FEV1 % predicted | 42 ± 21 | 54 ± 21 | 38 ± 17 | 42 ± 21 |
| DLCO % predicted* | 30 ± 15 | 35 ± 12 | 28 ± 17 | 25 ± 14 |
| Medications, n (%) | ||||
| Glucocorticoid steroid | 31 (46%) | 8 (40%) | 19 (48%) | 4 (50%) |
| Beta - blockade | 8 (12%) | 2 (10%) | 4 (10%) | 2 (25%) |
| Calcium channel blocker | 4 (6%) | 0 | 3 (7%) | 1 (13%) |
Data are mean ± SD or number (%), FFP: Fried Frailty Phenotype, COPD: Chronic Obstructive Pulmonary Disease, CF; Cystic Fibrosis, ILD; Interstitial Lung Disease, LAS; Lung Allocation Score, FVC: forced vital capacity; FEV1: Forced expiratory flow 1 second; DLCO, single breath diffusion capacity for carbon monoxide.
*
Sample size for DLCO was 62. Three participants could not perform an adequate DLCO maneuver and three participants had missing DLCO from their charts.