Table. Demographics, investigation results, and clinical details of asymptomatic JEV-infected blood donor and recipients, Hong Kong, China, May‒July 2017*.
Variable | Donor | Packed red blood cell recipient (index patient) | Platelet recipient | Plasma recipient |
---|---|---|---|---|
Underlying disease |
No history of disease, no recent travel to JEV-endemic regions outside Hong Kong; resides in JEV-endemic area Tin Shui Wai, Yuen Long |
End-stage chronic obstructive pulmonary disease with lung transplantation, May 10 |
Acute myeloid leukemia post induction chemotherapy with cytarabine and daunorubicin |
Intracranial hemorrhage |
Blood donation or transfusion type, date |
Blood donation, May 29 |
Packed red blood cell transfusion, June 22 |
Platelet transfusion, June 2 |
Plasma transfusion, June 20 |
Pretransfusion IgM serology result, date |
Specimen not available |
Serum negative, May 31 |
Serum negative, May 25 |
Specimen not available |
Posttransfusion IgM serology result, date |
Serum positive, July 22 |
CSF positive, July 11; serum positive, July 15 and 18 |
Serum positive, July 5 and 22 |
Specimen not available |
JEV nucleic acid test, specimen type and result, date |
Positive archived blood specimen |
Positive blood sample, June 26 and 28; positive bronchoalveolar lavage, July 10 |
Negative plasma sample, July 22; negative urine sample, July 25 |
Specimen not available |
Clinical symptoms |
Asymptomatic |
Fever and rash July 6 (14 d after transfusion), followed by decreased consciousness and myoclonic jerks; MRI showed typical appearance of T2 hyperintensity of bilateral thalami, substantia nigra, and medial temporal lobes |
Asymptomatic |
Unknown |
Outcome | Full recovery | Died October 1, 2017 | Full recovery | Died from respiratory failure 14 d after transfusion |
*CSF, cerebrospinal fluid; JEV, Japanese encephalitis virus; MRI, magnetic resonance imaging.