Figure 1. Mesenchymal loss of Lkb1 is sufficient to drive fully penetrant PJS polyposis in mice.

(A) Representative macroscopic images of wild-type, Lkb1^+/–, Lkb1^TwKO/+, and Lkb1^FspKO/+ mouse stomachs at 11 months of age. Scale bars: 5 mm. (B) Survival curve of Lkb1^+/– (n = 15), Lkb1^TwKO/+ (TwKO/+, n = 7), and Lkb1^FspKO/+ mice (FspKO/+, n = 27). Lkb1^FspKO/+ mice were followed until 17 months, with no mortality observed. (C and D) Comparison of polyp number (nr) (C) and diameter (D) in Lkb1^+/– (n = 15), Lkb1^TwKO/+ (TwKO/+, n = 6), and Lkb1^FspKO/+ mice (FspKO/+, n = 8) at 11 months of age. Lines depict mean and standard deviation. (E) Cre activity representing Lkb1 heterozygous cells as depicted by GFP signal in Lkb1^TwKO/+;R26R-mTmG mouse antral polyp. Representative image is shown. Scale bars: 500 μm and 100 μm (zoom-ins).