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. 2017 Dec 4;128(1):402–414. doi: 10.1172/JCI93597

Figure 4. Inactivation of AMPK does not lead to polyposis.

Figure 4

(A) Representative images of stomachs at 8 months of age with genotypes indicated. (B) Polyp number (left) and diameter (right) of mice of indicated genotypes at 8 months of age. Lkb1+/+;AMPKa1–/– (n = 4), Lkb1+/–; AMPKa1+/+ (n = 9), Lkb1+/-; AMPKa1–/– (n = 8). Lines depict mean and standard deviation. (C) Average polyp number (left) and diameter (right) of mice of indicated genotypes at 8 months of age. Lkb1+/+; AMPKa2–/– (n = 6), Lkb1+/–; AMPKa2+/+ (n = 10), Lkb1+/–; AMPKa2–/– (n = 10). Lines depict mean and standard deviation. (D) Representative images of stomachs at 17 months of age with genotypes indicated. (E) Average polyp number (left) and diameter (right) of mice of indicated genotypes at 17 months of age. Lkb1FspKO/+ (n = 27), AMPKa1–/–; AMPKa2FspKO/FspKO (n = 12). *P < 0.05 as assessed by unpaired t test. n.s., not significant. Lines in graphs depict mean and standard deviation. Two-tailed unpaired t test was used as a statistical test. Scale bars: 5 mm. nr, number; n.s., not significant.