Figure 7. Pharmacological JAK inhibition reduces polyposis.

(A) Outline of the experiment. Lkb1^FspKO/FspKO mice were treated with ruxolitinib or control for 6 weeks and sacrificed at about 20 weeks of age. (B) Quantification of polyp number (nr) in control and ruxolitinib-treated mice. Lines depict mean and standard deviation. (C) Quantification of total polyp area in control and ruxolitinib-treated mice. Two-tailed unpaired t test was used as a statistical test. (D) Macroscopic images of representative untreated and ruxolitinib-treated mouse stomachs. Scale bars: 50 mm.