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. 2017 Nov 20;128(1):190–206. doi: 10.1172/JCI95161

Figure 6. Gene augmentation therapy results in appropriate rod Cngb1 expression and restores Cnga1 expression.

Figure 6

(A) CNGβ1 (green: antibody targeted CNGβ1 distal to the mutation site) was expressed in the outer segments of the treated regions of Cngb1–/– retinae 3, 9, and 23 months after treatment. The untreated region from the retinae 3 months after injection and the 28-month-old untreated Cngb1–/– retinae did not express full-length CNGβ1. (B) CNGα1 (green) was expressed and correctly targeted to the photoreceptor outer segments in the treated regions of Cngb1–/– retinae 3, 9, and 23 months after treatment, but was not detectable in the untreated region. Scale bar: 50 μm.