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. 2017 Nov 20;128(1):207–218. doi: 10.1172/JCI94955

Figure 6. Expression of SS18-SSX2 in postnatal Prx1CreERT2 lineage induces synovial sarcomagenesis.

Figure 6

(A) Pre- and (B) post-dissection gross images as well as (C) a GFP fluorescence image demonstrating a representative submandibular tumor that occurred on 6 of 7 of the Prx1CreERT2 hSS2 mice. (D) Representative H&E histology photomicrograph shows typical features of a monophasic SS. Classic SS immunohistochemical staining demonstrates (E) cytoplasmic BCL2 and (F) nuclear TLE1. (G) Photomicrograph of X-gal staining of the mandible from a Prx1CreERT2 LacZ mouse showing the periosteal lineage (blue, left) as well as H&E staining of an SS tumor apparently arising from the same tissue layer in a Prx1CreERT2 hSS2 mouse (right), with adjacent enamel epithelium, a strong source of OPG production. Scale bars: 50 μm.