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. 2017 Dec 27;11:103–112. doi: 10.2147/OTT.S147184

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© 2018 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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Restoration of miR-199a suppressed proliferation and colony formation, but induced apoptosis in ccRCC cells.

Notes: (A) Restoration of miR-199a inhibited A498 cell proliferation. (B) Overexpression of miR-199a impeded colony-forming ability of A498 cells. (C) Exogenetic overexpression of miR-199a markedly reduced invasiveness of A498 cells, while ROCK1 restoration could partially block these effects (magnification, ×400). (D) miR-199a overexpression induced apoptosis in A498 cells, while exogenetic overexpression of ROCK1 blocked the miR-199a effect on apoptosis. *P<0.05.

Abbreviations: ccRCC, clear cell renal cell carcinoma; ctrl, control; ROCK1, Rho-associated coiled coil-containing protein kinase 1.