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. 2017 Dec 27;11:103–112. doi: 10.2147/OTT.S147184

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© 2018 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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miR-199a inhibited tumor growth in vivo.

Notes: (A) Stable transfection of miR-199a into A498 cells resulted in decreased growth and tumor weight. *P<0.05. (B) Immunohistochemical staining demonstrated that the tumors originating from LV-miR-199a cells had decreased expression of Ki-67 and ROCK1, compared with that from LV-ctrl cells (magnification, ×400). (C) We found an inverse correlation between the levels of miR-199a and mRNA expression of ROCK1.

Abbreviations: ctrl, control; LV, lentiviral vectors; ROCK1, Rho-associated coiled coil-containing protein kinase 1.