Table 1.
Baseline subject characteristics with hemispheric lesion verified by radiologic magnetic resonance imaging
| Variables | No IPSD n=338 Mean ± SD or n (%) |
IPSD n=187 Mean ± SD or n (%) |
t/χ2 | P-value |
|---|---|---|---|---|
| Female | 181 (53.6) | 115 (61.5) | 3.09 | 0.08 |
| Age | 65.4±10.9 | 67.4±11.4 | -2.00 | 0.05 |
| <9 years of education | 130 (38.5) | 67 (35.8) | 0.36 | 0.57 |
| Living alone | 40 (11.8) | 32 (16.0) | 1.85 | 0.17 |
| History of hypertension | 224 (66.3) | 130 (69.5) | 0.58 | 0.45 |
| History of diabetes | 114 (33.7) | 67 (35.8) | 0.24 | 0.63 |
| Lesion location | ||||
| Frontal lobe | 14 (4.1) | 14 (7.5) | 2.67 | 0.10 |
| Parietal lobe | 40 (11.8) | 18 (9.6) | 0.60 | 0.44 |
| Temporal lobe | 18 (5.3) | 11 (5.9) | 0.07 | 0.79 |
| Occipital lobe | 22 (6.5) | 14 (7.5) | 0.18 | 0.67 |
| Basal ganglia | 103 (30.5) | 68 (36.4) | 1.90 | 0.17 |
| Thalamus | 19 (5.6) | 26 (13.9) | 10.54 | <0.01 |
| Brainstem | 34 (10.1) | 18 (9.6) | 0.03 | 0.87 |
| Cerebellum | 22 (6.5) | 9 (4.8) | 0.62 | 0.43 |
| Other location | 18 (5.3) | 10 (5.3) | 0.00 | 0.99 |
| ≥ Two locations | 31 (9.2) | 11 (5.9) | 1.78 | 0.18 |
| BI | 71.48±16.11 | 68.90±17.34 | 1.71 | 0.09 |
| NIHSS score | 4.91±2.54 | 5.35±2.55 | -1.91 | 0.06 |
| BUN (mmol/L) | 5.17±1.56 | 5.23±1.60 | -0.43 | 0.67 |
| Cr (μmol/L) | 67.15±17.96 | 65.97±18.91 | 0.70 | 0.48 |
| ALT (U/L) | 21.77±9.28 | 20.42±9.13 | 1.61 | 0.11 |
| ALP (U/L) | 71.30±17.36 | 70.10±18.94 | 0.74 | 0.46 |
| HAMD17 | 2.95±2.03 | 3.04±2.00 | -0.45 | 0.66 |
| Uric acid (μmol/L) | 1.52 | 0.47 | ||
| ≤245.0 | 108 (32.0) | 69 (36.9) | 1.32 | 0.25 |
| 245.0–330.0 | 117 (34.6) | 57 (30.5) | 0.93 | 0.34 |
| ≥330.0 | 113 (33.4) | 61 (32.6) | 0.04 | 0.85 |
| Total bilirubin (μmol/L) | 10.89 | <0.01 | ||
| ≤8.0 | 119 (35.2) | 62 (33.2) | 0.22 | 0.64 |
| 8.0–12.8 | 124 (36.7) | 48 (25.7) | 6.64 | 0.01 |
| ≥12.8 | 95 (28.1) | 77 (41.2) | 9.34 | <0.01 |
Abbreviations: ALP, alkaline phosphatase; ALT, alanine transaminase; BI, Barthel Index; BUN, blood urea nitrogen; Cr, creatinine; HAMD17, 17-item Hamilton Depression Rating Scale; IPSD, postischemic stroke depression; NIHSS, National Institute of Health Stroke Scale.