Table 4.

Differences of immune expression in preoperative biopsy and tumor.

	Biopsy (median (range))	Tumor (median (range))	p
CD3+ stroma	387.3 (85.7–850.3)	252.5 (94.7–719.3)	n.s.
CD3+ epithel	9.0 (0.0–34.0)	3.0 (0–23)	n.s.
CD3+/MIB1+ stroma	4.8 (0.3–29.0)	2.3 (0–19)	n.s.
CD3+/MIB1+ epithel	0.5 (0.0–3.0)	0.0 (0–4)	n.s.
CD8+ stroma	65.0 (25.0–156.7)	103.5 (21.7–253.7)	0.036
CD8+ epithel	3.0 (0–17)	2.0 (0–21)	n.s.
GrzB+/CD8+ stroma	26.7 (12.7–79.7)	38.5 (0–167.3)	0.011
GrzB+/CD8+ epithel	2.0 (0–12)	2.0 (0–19)	n.s.
GrzB/CD8//CD8 stroma	0.60 (0–0.71)	0.46 (0.27–0.59)	0.007
GrzB/CD8//CD8 epithel	0.85 (0–1)	0.77 (0–1)	n.s.

Abbreviations: n.s.: not significant (P>0.05); CD: cluster of differentiation; MIB: mindbomb E3 ubiquitin protein ligase 1; GrzB: granzyme B.