Examples of treatment effect following radiotherapy of undifferentiated pleomorphic sarcoma. Representative photographs of H+E stained undifferentiated pleomorphic sarcoma of the extremity and trunk demonstrating increased tumor necrosis and hyalinization following radiotherapy. (A) Tumor with extensive hyalinization (H&E, 100x). (B) Tumor with extensive necrosis with ghost and degenerative tumor cells (H&E, 100x). (C) Tumors could also have a mix of both necrosis and hyalinization (H&E, 100x). Cytological changes consistent with treatment effect (inset, H&E, 200x) was also present in this sample.