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. 2017 Dec 18;7(2):e1393599. doi: 10.1080/2162402X.2017.1393599

Figure 6.

Figure 6.

Depletion of Ly6Clo monocytes with liposomal doxorubicin and anti-4-1BB antibody. (A) Numbers of circulating Ly6Chi and Ly6Clo monocytes in healthy or day 12 Eµ-myc tumor-bearing mice after treatment with Doxil (Dox-Lipo) i.v. on days 2 and 9, and/or anti-4-1BB mAb i.p. on days 5 and 12. (B) Tumor burden in the blood over time following the indicated treatments, and (C) numbers of tumor cells in blood at day 12. (D) Numbers of circulating Ly6Chi and Ly6Clo monocytes in tumor-bearing mice on day 15. (E) Survival of Eµ-myc tumor-bearing mice receiving the indicated treatments. (* p < 0.05; ** p < 0.01; *** p < 0.001; n = 5 per group).