Table 3. Fungal growth inhibition by compounds 4–12.
MIC is defined as 50% growth inhibition, n = 3–6. FLC: fluconazole; VRC: voriconazole; AMB: amphotericin B.
| Growth inhibition MIC [μM] | EC50 [μM] | |||||
|---|---|---|---|---|---|---|
| ID | Saccharomyces cerevisiae ATCC 9763 | Candida albicans SC5314 | Candida krusei ATCC 6258 | Candida glabrata ATCC 90030 | Candida glabrata Cg003 | HepG2 (72 h) |
| 4 | 7.5 ±0.0 | 100 ±43 | 66 ±16 | 23.7 ±0.0 | 75 ±0.0 | 3.50 ±1.87 |
| 5 | 11.6 ±8.1 | 150 ±0.0 | 150 ±0.0 | 46.5 ±27 | >75 | 4.70 ±3.40 |
| 6 | 5.0 ±2.9 | 7.5 ±0.0 | 7.5 ±0.0 | 12.1 ±7.9 | >75 | 16.69 ±3.54 |
| 7 | 1.5 ± 0.0 | 15 ±0.0 | 4.7 ±0.0 | 15 ±0.0 | >75 | 14.87 ±0.26 |
| 8 | 6.2 ±2.6 | 7.5 ±0.0 | 12.9 ±9.4 | 5.3 ±2.7 | >75 | 13.60 ±1.33 |
| 9 | 7.5 ±0.0 | 7.5 ±0.0 | 7.5 ±4.8 | 7.5 ±0.0 | 23.7 ±0.0 | 12.45 ±3.68 |
| 10 | 7.5 ±0.0 | 6.8 ±4.6 | 6.8 ±4.6 | 21.0 ±6.6 | >75 | 18.64 ±1.12 |
| 11a | >20 | >20 | >20 | >20 | >20 | >20 |
| 12a | >20 | >20 | >20 | >20 | >20 | >20 |
| FLC | 20.68 ±8.68 | 0.75 ±0.48 | 67.17 ±26.98 | 26.12 ±0.0 | >208 | >50 |
| VRC | 0.27 ±0.19 | 0.03 ±0.02 | 1.02 ±0.70 | 0.61 ±0.28 | 6.11 ±2.64 | >50 |
| AMB | 0.02 ±0.01 | 0.10 ±0.04 | 0.44 ±0.34 | 0.10±0.04 | 0.18±0.08 | 0.69 ±0.01 |
aThe compounds were tested in concentrations up to 75 μM in the fungal growth assay and up to 50 μM against HepG2 cells, but compound precipitation was observed at concentrations above 20 μM.