Table 1. Frequency, average effect, and respective standard error of haplotypes alleles located in the PAPP-A2 gene.

Alleles Haplotypes 16jc6	Bases of the SNPs	Frequency	Average effect	Standard error
Allele 1	AGACCGCGTAAATGGTTTCA	0.527762	-18.0658	27.5808
Allele 2	AAACAAAGTAGGCGTTCTCC	0.109384	-119.58	45.1731
Allele 3	GAACAAAGTAGGCGTTCTCC	0.110772	55.0690	44.3902
Allele 4	AGACCGCAGGAACAGTTTCC	0.078845	-95.5179	51.3268
Allele 5	AGACCGCGTGGACGGTTTCC	0.063021	-78.7045	56.9129
Allele 6	AGACCGCAGGAACAGTTTCA	0.057746	49.6128	61.1468
Allele 7	AGGTCGCAGGAACGGCTCTC	0.052471	207.18	59.5146
Haplotype 16kc3
Allele 1	CGAAT	0.582454	-19.2422	15.1954
Allele 2	AAGGC	0.222654	-27.9854	18.0778
Allele 3	CGGAT	0.143254	-56.2382	20.7453
Allele 4	AAGAC	0.051638	103.47	29.6901
Haplotype 16lc3
Allele 1	GCCGG	0.616602	-16.5193	15.4988
Allele 2	GCTAG	0.228207	-14.7703	18.5367
Allele 3	GTTAA	0.092171	-64.6040	24.6625
Allele 4	ACATG	0.063021	95.8936	28.8740
Haplotype 16vc4
Allele 1	TTGGTTCATAGGGGTTTC	0.495835647	16.5989	20.4811
Allele 2	TCGGTTCATAGGGGTTTC	0.242365353	31.8859	23.7671
Allele 3	CCAGTTCATAGGGGTTGC	0.165463631	35.6756	26.4293
Allele 4	CCAACCAGCCAAAAGGGT	0.068017768	42.6865	39.5794
Allele 5	CCAGTTCGTAGGGGTTTC	0.028317601	-126.85	42.6491