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. Author manuscript; available in PMC: 2018 Jun 13.
Published in final edited form as: Nature. 2017 Dec 13;552(7685):368–373. doi: 10.1038/nature25023

Figure 4. Cryo-EM structure of RHEB-mTORC1.

Figure 4

a, One copy of the RHEB-mTOR-RAPTOR-mLST8-4EBP1 complex. mTOR colored according to linear schematic (hatched blue box, extension of conventional FAT boundary), RHEB red, RAPTOR purple, mLST8 green, 4EBP1 TOS magenta. AMPPNP-Mg2+ and GTPγS-Mg2+ in CPK representation (dotted lines, disordered N-heat–M-heat and M-heat–FAT linkers). b, Dimeric mTORC1 oriented similarly to a (top) and rotated as shown (bottom). The two mTOR are cyan and orange, and the other subunits as in a. c, RHEB-GTPγS interface with mTOR N-heat, M-heat and FAT, showing side chains and backbone groups within inter- and intra-molecular contact distance. RHEB is pink, switch regions dark red. FAT residues 1261–1266 omitted for clarity.