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. Author manuscript; available in PMC: 2018 Jun 13.
Published in final edited form as: Nature. 2017 Dec 13;552(7685):368–373. doi: 10.1038/nature25023

Extended Data Figure 2. RAPTOR-4EBP1 TOS interface and density in the Cryo-EM structure of mTORC1.

Extended Data Figure 2

a, Human RAPTOR-4EBP1 TOS interface from the 3.0 Å refined human mTORC1 cryo-EM structure, colored as in Figure 2b. Only the RAPTOR side chains that make hydrogen bond (red dotted lines), electrostatic or van der Waals contacts to 4EBP1 are shown. b, Stereo view of the cryo-EM density of the human RAPTOR-4EBP1 TOS interface. Although the complex contained full-length 4EBP1, only an 8-residue segment is ordered in the cryo-EM reconstruction (also see Extended Data Fig. 7a). c, Cryo-EM data collection and refinement statistics.