. Author manuscript; available in PMC: 2019 Jan 1.

Published in final edited form as: Kidney Int. 2017 Aug 31;93(1):252–259. doi: 10.1016/j.kint.2017.06.028

Table 4. Adjusted Hazard Ratios for Incident Chronic Kidney Disease by Quartile of Plasma Galectin-3 Stratified by Hypertension Status.

Hypertension Status	Model	Quartile of Plasma Level of Galectin-3 (Range, ng/mL)				P-value

		Quartile 1 (4.4-12.0)	Quartile 2 (12.1-14.1)	Quartile 3 (14.2-16.7)	Quartile 4 (16.8-91.6)
Hypertension	1^a	1 [Ref]	1.43 (1.19-1.72)	1.73 (1.43-2.10)	2.57 (2.10-3.14)	<0.001
	2^b	1 [Ref]	1.33 (1.10-1.60)	1.51 (1.24-1.83)	2.11 (1.72-2.60)	<0.001
	3^c	1 [Ref]	1.33 (1.10-1.59)	1.50 (1.24-1.82)	2.05 (1.67-2.53)	<0.001
	4^d	1 [Ref]	1.29 (1.07-1.55)	1.44 (1.19-1.75)	1.94 (1.57-2.39)	<0.001

No Hypertension	1^a	1 [Ref]	1.02 (0.82-1.27)	1.28 (1.01-1.61)	1.79 (1.37-2.34)	<0.001
	2^b	1 [Ref]	0.96 (0.77-1.20)	1.16 (0.92-1.46)	1.55 (1.18-2.02)	0.001
	3^c	1 [Ref]	0.96 (0.77-1.19)	1.15 (0.91-1.46)	1.51 (1.15-1.98)	0.002
	4^d	1 [Ref]	0.95 (0.77-1.19)	1.14 (0.90-1.44)	1.48 (1.13-1.95)	0.003

Model 1: adjusted for age, sex, race-center, education level, physical activity, smoking status, body mass index, systolic blood pressure, anti-hypertensive medication use, history of cardiovascular disease, diabetes status, fasting blood glucose, rs4644

Model 2: Model 1 + estimated glomerular filtration rate-creatinine

Model 3: Model 2 + urine albumin-to-creatinine ratio

Model 4: Model 3 + troponin T, N-terminal pro B-type natriuretic peptide