. Author manuscript; available in PMC: 2019 Jan 1.

Published in final edited form as: Alzheimers Dement. 2017 Jul 8;14(1):1–9. doi: 10.1016/j.jalz.2017.05.005

Table 3.

Joint effects between physical activity (PA) and APOE ε4 allele or diabetic status on incident dementia/CIND^a

	High level of PA ^b			Low level of PA ^b
	case/total	Crude HR (95% CI)	Adjust HR (95% CI)	case/total	Crude HR (95% CI)	Adjust HR (95% CI)
APOE ε4
No	52/765	1.00	1.00	52/432	1.79 (1.22–2.63)	1.39 (0.94–2.07)
Yes	19/172	1.96 (1.16–3.32)	2.20 (1.29–3.74)	13/69	2.80 (1.53–5.15)	3.44 (1.85–6.39)
Diabetes
No	37/636	1.00	1.00	38/346	2.07 (1.32–3.26)	1.55 (0.97–2.48)
Yes	34/261	2.75 (1.73–7.39)	2.39 (1.49–3.84)	27/195	3.13 (1.91–9.15)	3.11 (1.87–5.18)

Measure of interaction on additive scale: RERI (95% CI): PA and ε4 = 0.85 (−1.34–3.04); PA and diabetes = 0.16 (−1.40–1.73)

Abbreviation: APOE, apolipoprotein E; CIND, cognitive impairment without dementia; HR, hazard ratio; CI, confidence interval; RERI, relative excess risk due to interaction.

Cox proportional model adjusted for gender and baseline age (years), diabetes or APOE ε4, education, smoking status, history of stroke and hours of standing or walking at work.

PA cutoff = 35 MET-hour/week