Table 4.

Associations between obstructive sleep apnea and cardiovascular disease/ non-cardiac vascular disease / any cardio- or cerebrovascular disease related mortality in 813 patients with rheumatoid arthritis (RA) and 811 subjects without RA.

	Rheumatoid arthritis			Non-rheumatoid arthritis
Outcome	N events	HR† (95% CI)	HR* (95% CI)	N events	HR† (95% CI)	HR* (95% CI)	p-value**
Cardiovascular disease	168	1.88 (1.08, 3.27)	1.77 (1.01, 3.10)	124	1.87 (1.02, 3.42)	1.64 (0.89, 3.03)	0.84
Myocardial infarction	50	0.94 (0.32, 2.74)	0.92 (0.31, 2.72)	45	2.09 (0.84, 5.21)	2.02 (0.78, 5.21)	0.31
Heart failure	10	1.07 (0.47, 2.41)	0.98 (0.43, 2.23)	83	1.37 (0.61, 3.10)	1.29 (0.56, 2.96)	0.71
Non-cardiac vascular event	91	1.93 (0.95, 3.92)	1.71 (0.84, 3.50)	51	2.10 (0.97, 4.51)	2.04 (0.92, 4.51)	0.24
Cerebrovascular disease	65	2.44 (1.14, 5.26)	2.01 (0.92, 4.39)	31	2.18 (0.86, 5.55)	2.46 (0.91, 6.66)	0.49
Peripheral vascular disease	43	1.17 (0.34, 3.98)	1.28 (0.37, 4.46)	25	3.09 (1.1, 8.28)	2.58 (0.92, 7.26)	0.057
Any CVD or non-cardiac vascular event	211	1.76 (1.04, 2.98)	1.68 (0.98, 2.85)	157	1.62 (0.93, 2.83)	1.57 (0.89, 2.76)	0.86
Overall mortality	323	1.20 (0.81, 1.78)	1.24 (0.82, 1.86)	248	0.69 (0.38, 1.26)	0.76 (0.42, 1.40)	0.12

Abbreviations: CI= confidence interval; CVD=cardiovascular disease; HF=heart failure; HR= hazard ratio; MI=myocardial infarction; N=number; PAD= peripheral arterial disease; RA=rheumatoid arthritis.

^†Adjusted for age, sex and calendar year of RA incidence/index date.

^*Adjusted for ages, sex, calendar year of RA incidence/index date, smoking, hypertension, obesity (BMI sity on, obesity x, calendar year of RA incidenc.

^**p-value for interaction between RA/non-RA status and obstructive sleep apnea status