Time courses of abundance change for mRNAs coding for protein kinases (left) and TFs (right) involved in regulation of cell-cycle. All six cell-cycle related transcripts (black) showed significant increases only on Days 2 and 4. Only Foxm1 was significantly changed on Day 1, a decrease. Abundant non-cell-cycle transcripts (Prkaca and Hoxb7), shown in red, are included as controls. Cdk1, Cyclin-dependent kinase 1; Plk1, Polo-like kinase 1; Aurkb, Aurora B kinase, Prkaca, Protein kinase A catalytic α; E2f1, E2F TF 1; Timeless, timeless circadian clock; Foxm1, Forkhead Box M1; Hoxb7, Homeobox B7.