Table 3.
Effect of disulfiram on other measures of the rGT at either the 30- or 120-min pre-treatment time for the optimal (n = 29, 120 min; n = 27, 30 min) and suboptimal (n = 10, 120 min; n = 12, 30 min) groups. Data presented are mean ± SEM
| Variable | Group | Doses (mg/kg)
|
|||||
|---|---|---|---|---|---|---|---|
| Vehicle | 10 | 25 | 50 | 75 | 100 | ||
| 30-min pre-treatment | |||||||
| Trials | Optimal** | 106 ± 6.9 | 113 ± 6.7 | 115 ± 6.4 | 112 ± 5.7 | 115 ± 5.6 | 111 ± 5.7 |
| Suboptimal | 75 ± 3.4 | 71 ± 3.6 | 73 ± 2.3 | 76 ± 3.4 | 77 ± 5.5 | 67 ± 4.5 | |
| % premature | Optimal** | 11 ± 1.5 | 11 ± 1.6 | 11 ± 1.8 | 11 ± 1.6 | 10 ± 1.4 | 10 ± 1.6 |
| Suboptimal | 16 ± 2.4 | 19 ± 2.1 | 17 ± 1.9 | 16 ± 2 | 17 ± 2.3 | 17 ± 3.6 | |
| Reward perseverative | Optimal | 0.01 ± 0.004 | 0.001 ± 0.001 | 0.02 ± 0.01 | 0.005 ± 0.002 | 0.007 ± 0.002 | 0.013 ± 0.01 |
| Suboptimal | 0.015 ± 0.01 | 0.04 ± 0.02 | 0.002 ± 0.001 | 0.02 ± .01 | 0.03 ± 0.02 | 0.03 ± 0.03 | |
| Punishment perseverative | Optimal | 0.052 ± 0.01 | 0.047 ± 0.01 | 0.055 ± 0.01 | 0.048 ± 0.004 | 0.049 ± 0.01 | 0.05 ± 0.01 |
| Suboptimal | 0.048 ± 0.01 | 0.042 ± 0.01 | 0.050 ± 0.01 | 0.049 ± 0.01 | 0.051 ± 0.01 | 0.048 ± 0.01 | |
| Choice latency | Optimal | 1.13 ± 0.14 | 1.21 ± .19 | 1.26 ± 0.20 | 1.26 ± 0.20 | 1.27 ± 0.18 | 1.29 ± 0.19 |
| Suboptimal | 1.0 ± 0.15 | 0.86 ± 0.12 | 1.09 ± 0.16 | 1.1 ± 0.14 | 1.06 ± 0.16 | 1.27 ± 0.20 | |
| Collect latency | Optimal | 3.08 ± 1.22 | 1.44 ± 0.06 | 3.05 ± 1.60 | 1.46 ± 0.06 | 1.49 ± 0.08 | 1.95 ± 0.36 |
| Suboptimal | 1.28 ± 0.07 | 1.26 ± 0.09 | 1.24 ± 0.08 | 1.24 ± 0.07 | 1.20 ± 0.06 | 2.89 ± 1.60 | |
| % omissions | Optimal | 0.82 ± 0.36 | 1.15 ± 0.61 | 1.36 ± 0.55 | 1.58 ± 0.81 | 1.34 ± 0.54 | 1.12 ± 0.34 |
| Suboptimal | 1.40 ± 0.98 | 3.6 ± 2.48 | 1.12 ± 0.63 | 0.73 ± 0.28 | 1.05 ± 0.35 | 2.81 ± 2.46 | |
| 120-min pre-treatment | |||||||
| Trials | Optimal** | 113 ± 7.88 | 115 ± 7.64 | 108 ± 5.25 | 112 ± 5.62 | 104 ± 4.31 | 107 ± 6.79 |
| Suboptimal | 67 +± 6.37 | 71 ± 5.13 | 81 ± 9.23 | 77 ± 6.9 | 73 ± 5.7 | 75 ± 5.51 | |
| % premature | Optimal** | 13 ± 1.6 | 12 ± 1.4 | 11 ± 1.2 | 11 ± 1.2 | 14 ± 1.4 | 14 ± 1.7 |
| Suboptimal | 20 ± 3.8 | 17 ± 2.8 | 20 ± 2.4 | 18 ± 2.7 | 20 ± 2.9 | 16 ± 2.8 | |
| Reward perseverative | Optimal | 0.45 ± 0.13 | 0.38 ± 0.11 | 0.45 ± 0.13 | 0.46 ± 0.15 | 0.64 ± 0.18 | 0.41 ± 0.11 |
| Suboptimal | 0.02 ± 0.01 | 0.05 ± 0.02 | 0.03 ± 0.02 | 0.03 ± 0.01 | 0.02 ± 0.01 | 0.02 ± 0.01 | |
| Punishment perseverative | Optimal | 0.056 ± 0.01 | 0.049 ± 0.01 | 0.049 ± 0.01 | 0.052 ± 0.004 | 0.052 ± 0.01 | 0.049 ± 0.005 |
| Suboptimal | 0.051 ± 0.01 | 0.063 ± 0.01 | 0.053 ± 0.01 | 0.058 ± 0.01 | 0.050 ± 0.01 | 0.058 ± 0.01 | |
| Choice latency | Optimal | 0.95 ± 0.12 | 0.92 ± 0.11 | 0.96 ± 0.12 | 0.99 ± 0.15 | 0.95 ± 0.12 | 1.01 ± 0.15 |
| Suboptimal | 1.36 ± 0.16 | 1.33 ± 0.21 | 1.08 ± 0.12 | 1.04 ± 0.06 | 1.02 ± 0.12 | 1.26 ± 0.13 | |
| Collect latency | Optimal | 1.74 ± 0.43 | 1.35 ± 0.05 | 1.38 ± 0.07 | 1.33 ± 0.05 | 1.32 ± 0.05 | 1.31 ± 0.05 |
| Suboptimal | 1.37 ± 1.13 | 1.36 ± 0.13 | 1.34 ± 0.09 | 1.36 ± 0.10 | 1.34 ± 0.09 | 1.37 ± 0.11 | |
| % omissions | Optimal | 1.55 ± 0.79 | 0.85 ± 0.33 | 0.89 ± 0.37 | 1.47 ± 0.91 | 0.77 ± 0.38 | 1.10 ± 0.58 |
| Suboptimal | 1.14 ± 0.38 | 0.42 ± 0.22 | 0.78 ± 0.48 | 0.36 ± 0.19 | 1.32 ± 0.89 | 1.08 ± 0.57 | |
A significant effect of group (p < 0.05)