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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Atherosclerosis. 2017 Sep 21;268:196–206. doi: 10.1016/j.atherosclerosis.2017.08.031

Fig. 2.

Fig. 2

Silencing of hepatic Angptl3 lowered LDL-C, but not HDL-C, level in hCETP/ApoB-100 mice.

hCETP/ApoB-100 mice were injected with Luc or Angptl3 siRNAs. Blood samples were collected one day before injection (baseline), and on day 3, 10, 14 and 24 after injection. TG, TC, HDL-C and LDL-C were measured. TG, TC, HDL-C and LDL-C levels from individual mouse (A) and averages of each group (B) are shown. Standard deviations were calculated from 4 mice of each group. p values (ANOVA) in (A) were calculated by comparing the Angptl3 siRNA with Luc siRNA groups. p values (t-test) in (B) were calculated by comparing Angptl3 siRNA with Luc siRNA groups at the days indicated.