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. Author manuscript; available in PMC: 2018 Jan 3.
Published in final edited form as: J Pharm Sci. 2014 Dec 1;104(2):740–749. doi: 10.1002/jps.24283

FIGURE 6.

FIGURE 6

Effect of stabilizing excipient combinations on HA activity after drying influenza vaccine on PDMS chips and storing with desiccant for up to six months at 40°C. Vaccine (B/Brisbane/60/2008) was formulated with two, three or four stabilizing excipients at a total stabilizer concentration of 10% w/v in ammonium acetate buffer. For the two-stabilizer combinations, the concentration ratio is shown, where the first number corresponds to the first excipient listed below it on the x axis. The combinations of three or four stabilizers all contained equal amounts of each excipient. T = trehalose, S = sucrose, A = arginine, H = sodium heptagluconate. Asterisk (*) indicates HA activity significantly decreased from HA activity on day 0 (Student’s t-test, p < 0.05). HA activity is shown as a percentage of concentrated stock vaccine solution. Data represent averages of n = 12 replicates, with standard deviation bars shown.