Fig. 6.

DUSP1 regulation by GB chemotherapeutic agents. U251 and U343 GB cell lines (a) and GB TSCs (b) were treated with the steroid dexamethasone (DEX), or the chemotherapeutics temozolomide (TMZ), camptothecin (CPT), and topotecan (TOPO) for 24 h. Fold-induction responses for DUSP1 gene expression were determined by qPCR analysis relative to vehicle (DMSO) treated controls and are presented on a log2 scale (n = 3 per group). Statistical significance was assessed using one-way ANOVA with Bonferroni correction to account for multiple comparisons (**** = p < 0.0001)