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. 2017 Nov 24;10(1-3):95–103. doi: 10.1007/s12307-017-0202-0

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Effect of SR11302 on metastasis in ex vivo 4D model with H1299 cells: a-f hematoxylin and eosin images of right upper (A & D) on day 10, right middle (B & E) on day 15 and right lower (C & F) on day 20. The untreated control 4D lung has more metastatic lesion (A, B & C) compared to the SR11302-treated lung in 40X high power field image. g Graph shows significant difference in number of per high-power field (HPF) in metastatic lesion for 4D model seeded with H1299 compared to control on day 10 (p = 0.0001), day 15 (p < 0.0001) and day 20 (p = 0.02)